The John Edmiston House is a historic house on Main Street in Canehill, Arkansas. Built in 1896, this 2+1⁄2-story wood-frame structure is the small community's most architecturally elaborate Victorian house. It has asymmetrical massing and a busy and varied roofline, with numerous projections, gables, and porches, all characteristic of the Queen Anne and Eastlake styles. The builder, John Edmiston, was a prominent local businessman and banker.